RapamycinFungusV1, Main, Exploration, bibRecord, 000523

Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.

Identifieur interne : 000523 ( Main/Exploration ); précédent : 000522; suivant : 000524

Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.

Auteurs : Yuanxing Gu [République populaire de Chine] ; Yingshan Zhou [République populaire de Chine] ; Xinfeng Shi [République populaire de Chine] ; Yongping Xin [République populaire de Chine] ; Ying Shan [République populaire de Chine] ; Cong Chen [République populaire de Chine] ; Tong Cao [République populaire de Chine] ; Weihuan Fang [République populaire de Chine] ; Xiaoliang Li [République populaire de Chine]

Source :

Archives of virology [ 1432-8798 ] ; 2018.

RBID : pubmed:29177545

Descripteurs français

KwdFr :
- Adénine (analogues et dérivés), Adénine (pharmacologie), Androstadiènes (pharmacologie), Animaux (MeSH), Autophagie (effets des médicaments et des substances chimiques), Autophagie (génétique), Cellules épithéliales (effets des médicaments et des substances chimiques), Cellules épithéliales (métabolisme), Cellules épithéliales (virologie), Gènes rapporteurs (MeSH), Interactions hôte-pathogène (MeSH), Lignée cellulaire (MeSH), Petit ARN interférent (génétique), Petit ARN interférent (métabolisme), Protéine-5 associée à l'autophagie (antagonistes et inhibiteurs), Protéine-5 associée à l'autophagie (génétique), Protéine-5 associée à l'autophagie (métabolisme), Protéines associées aux microtubules (génétique), Protéines associées aux microtubules (métabolisme), Protéines à fluorescence verte (génétique), Protéines à fluorescence verte (métabolisme), Rein (MeSH), Régulation de l'expression des gènes (MeSH), Réplication virale (effets des médicaments et des substances chimiques), Réplication virale (génétique), Sirolimus (pharmacologie), Suidae (MeSH), Teschovirus (croissance et développement), Teschovirus (effets des médicaments et des substances chimiques), Teschovirus (génétique), Teschovirus (métabolisme), Transduction du signal (MeSH), Wortmannine (MeSH).
MESH :
- analogues et dérivés : Adénine.
- antagonistes et inhibiteurs : Protéine-5 associée à l'autophagie.
- croissance et développement : Teschovirus.
- effets des médicaments et des substances chimiques : Autophagie, Cellules épithéliales, Réplication virale, Teschovirus.
- génétique : Autophagie, Petit ARN interférent, Protéine-5 associée à l'autophagie, Protéines associées aux microtubules, Protéines à fluorescence verte, Réplication virale, Teschovirus.
- métabolisme : Cellules épithéliales, Petit ARN interférent, Protéine-5 associée à l'autophagie, Protéines associées aux microtubules, Protéines à fluorescence verte, Teschovirus.
- pharmacologie : Adénine, Androstadiènes, Sirolimus.
- virologie : Cellules épithéliales.
- Animaux, Gènes rapporteurs, Interactions hôte-pathogène, Lignée cellulaire, Rein, Régulation de l'expression des gènes, Suidae, Transduction du signal, Wortmannine.

English descriptors

KwdEn :
- Adenine (analogs & derivatives), Adenine (pharmacology), Androstadienes (pharmacology), Animals (MeSH), Autophagy (drug effects), Autophagy (genetics), Autophagy-Related Protein 5 (antagonists & inhibitors), Autophagy-Related Protein 5 (genetics), Autophagy-Related Protein 5 (metabolism), Cell Line (MeSH), Epithelial Cells (drug effects), Epithelial Cells (metabolism), Epithelial Cells (virology), Gene Expression Regulation (MeSH), Genes, Reporter (MeSH), Green Fluorescent Proteins (genetics), Green Fluorescent Proteins (metabolism), Host-Pathogen Interactions (MeSH), Kidney (MeSH), Microtubule-Associated Proteins (genetics), Microtubule-Associated Proteins (metabolism), RNA, Small Interfering (genetics), RNA, Small Interfering (metabolism), Signal Transduction (MeSH), Sirolimus (pharmacology), Swine (MeSH), Teschovirus (drug effects), Teschovirus (genetics), Teschovirus (growth & development), Teschovirus (metabolism), Virus Replication (drug effects), Virus Replication (genetics), Wortmannin (MeSH).
MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , antagonists & inhibitors : Autophagy-Related Protein 5.
- chemical , genetics : Autophagy-Related Protein 5, Green Fluorescent Proteins, Microtubule-Associated Proteins, RNA, Small Interfering.
- chemical , metabolism : Autophagy-Related Protein 5, Green Fluorescent Proteins, Microtubule-Associated Proteins, RNA, Small Interfering.
- chemical , pharmacology : Adenine, Androstadienes, Sirolimus.
- drug effects : Autophagy, Epithelial Cells, Teschovirus, Virus Replication.
- genetics : Autophagy, Teschovirus, Virus Replication.
- growth & development : Teschovirus.
- metabolism : Epithelial Cells, Teschovirus.
- virology : Epithelial Cells.
- Animals, Cell Line, Gene Expression Regulation, Genes, Reporter, Host-Pathogen Interactions, Kidney, Signal Transduction, Swine, Wortmannin.

Abstract

Autophagy is a homeostatic process that has been shown to be vital in the innate immune defense against pathogens. However, little is known about the regulatory role of autophagy in porcine teschovirus 2 (PTV-2) replication. In this study, we found that PTV-2 infection induces a strong increase in GFP-LC3 punctae and endogenous LC3 lipidation. However, PTV-2 infection did not enhance autophagic protein degradation. When cellular autophagy was pharmacologically inhibited by wortmannin or 3-methyladenine, PTV-2 replication increased. The increase in virus yield via autophagy inhibition was further confirmed by silencing atg5, which is required for autophagy. Furthermore, PTV-2 replication was suppressed when autophagy was activated by rapamycin. Together, the results suggest that PTV-2 infection activates incomplete autophagy and that autophagy then inhibits further PTV-2 replication.

DOI: 10.1007/s00705-017-3652-2
PubMed: 29177545

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000667
to stream Main, to step Curation: 000667

Le document en format XML

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<author><name sortKey="Shi, Xinfeng" sort="Shi, Xinfeng" uniqKey="Shi X" first="Xinfeng" last="Shi">Xinfeng Shi</name>
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<author><name sortKey="Xin, Yongping" sort="Xin, Yongping" uniqKey="Xin Y" first="Yongping" last="Xin">Yongping Xin</name>
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<author><name sortKey="Shan, Ying" sort="Shan, Ying" uniqKey="Shan Y" first="Ying" last="Shan">Ying Shan</name>
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<author><name sortKey="Chen, Cong" sort="Chen, Cong" uniqKey="Chen C" first="Cong" last="Chen">Cong Chen</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058</wicri:regionArea>
<orgName type="university">Université de Zhejiang</orgName>
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<author><name sortKey="Cao, Tong" sort="Cao, Tong" uniqKey="Cao T" first="Tong" last="Cao">Tong Cao</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058</wicri:regionArea>
<orgName type="university">Université de Zhejiang</orgName>
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<author><name sortKey="Fang, Weihuan" sort="Fang, Weihuan" uniqKey="Fang W" first="Weihuan" last="Fang">Weihuan Fang</name>
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<author><name sortKey="Li, Xiaoliang" sort="Li, Xiaoliang" uniqKey="Li X" first="Xiaoliang" last="Li">Xiaoliang Li</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenine (analogs & derivatives)</term>
<term>Adenine (pharmacology)</term>
<term>Androstadienes (pharmacology)</term>
<term>Animals (MeSH)</term>
<term>Autophagy (drug effects)</term>
<term>Autophagy (genetics)</term>
<term>Autophagy-Related Protein 5 (antagonists & inhibitors)</term>
<term>Autophagy-Related Protein 5 (genetics)</term>
<term>Autophagy-Related Protein 5 (metabolism)</term>
<term>Cell Line (MeSH)</term>
<term>Epithelial Cells (drug effects)</term>
<term>Epithelial Cells (metabolism)</term>
<term>Epithelial Cells (virology)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>Genes, Reporter (MeSH)</term>
<term>Green Fluorescent Proteins (genetics)</term>
<term>Green Fluorescent Proteins (metabolism)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Kidney (MeSH)</term>
<term>Microtubule-Associated Proteins (genetics)</term>
<term>Microtubule-Associated Proteins (metabolism)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>RNA, Small Interfering (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Sirolimus (pharmacology)</term>
<term>Swine (MeSH)</term>
<term>Teschovirus (drug effects)</term>
<term>Teschovirus (genetics)</term>
<term>Teschovirus (growth & development)</term>
<term>Teschovirus (metabolism)</term>
<term>Virus Replication (drug effects)</term>
<term>Virus Replication (genetics)</term>
<term>Wortmannin (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénine (analogues et dérivés)</term>
<term>Adénine (pharmacologie)</term>
<term>Androstadiènes (pharmacologie)</term>
<term>Animaux (MeSH)</term>
<term>Autophagie (effets des médicaments et des substances chimiques)</term>
<term>Autophagie (génétique)</term>
<term>Cellules épithéliales (effets des médicaments et des substances chimiques)</term>
<term>Cellules épithéliales (métabolisme)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Gènes rapporteurs (MeSH)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Petit ARN interférent (génétique)</term>
<term>Petit ARN interférent (métabolisme)</term>
<term>Protéine-5 associée à l'autophagie (antagonistes et inhibiteurs)</term>
<term>Protéine-5 associée à l'autophagie (génétique)</term>
<term>Protéine-5 associée à l'autophagie (métabolisme)</term>
<term>Protéines associées aux microtubules (génétique)</term>
<term>Protéines associées aux microtubules (métabolisme)</term>
<term>Protéines à fluorescence verte (génétique)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
<term>Rein (MeSH)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Réplication virale (effets des médicaments et des substances chimiques)</term>
<term>Réplication virale (génétique)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Suidae (MeSH)</term>
<term>Teschovirus (croissance et développement)</term>
<term>Teschovirus (effets des médicaments et des substances chimiques)</term>
<term>Teschovirus (génétique)</term>
<term>Teschovirus (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
<term>Wortmannine (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Autophagy-Related Protein 5</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Autophagy-Related Protein 5</term>
<term>Green Fluorescent Proteins</term>
<term>Microtubule-Associated Proteins</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Autophagy-Related Protein 5</term>
<term>Green Fluorescent Proteins</term>
<term>Microtubule-Associated Proteins</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adenine</term>
<term>Androstadienes</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénine</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéine-5 associée à l'autophagie</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term>
<term>Epithelial Cells</term>
<term>Teschovirus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Autophagie</term>
<term>Cellules épithéliales</term>
<term>Réplication virale</term>
<term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autophagy</term>
<term>Teschovirus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autophagie</term>
<term>Petit ARN interférent</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Protéines associées aux microtubules</term>
<term>Protéines à fluorescence verte</term>
<term>Réplication virale</term>
<term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelial Cells</term>
<term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Petit ARN interférent</term>
<term>Protéine-5 associée à l'autophagie</term>
<term>Protéines associées aux microtubules</term>
<term>Protéines à fluorescence verte</term>
<term>Teschovirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adénine</term>
<term>Androstadiènes</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Gene Expression Regulation</term>
<term>Genes, Reporter</term>
<term>Host-Pathogen Interactions</term>
<term>Kidney</term>
<term>Signal Transduction</term>
<term>Swine</term>
<term>Wortmannin</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Gènes rapporteurs</term>
<term>Interactions hôte-pathogène</term>
<term>Lignée cellulaire</term>
<term>Rein</term>
<term>Régulation de l'expression des gènes</term>
<term>Suidae</term>
<term>Transduction du signal</term>
<term>Wortmannine</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Autophagy is a homeostatic process that has been shown to be vital in the innate immune defense against pathogens. However, little is known about the regulatory role of autophagy in porcine teschovirus 2 (PTV-2) replication. In this study, we found that PTV-2 infection induces a strong increase in GFP-LC3 punctae and endogenous LC3 lipidation. However, PTV-2 infection did not enhance autophagic protein degradation. When cellular autophagy was pharmacologically inhibited by wortmannin or 3-methyladenine, PTV-2 replication increased. The increase in virus yield via autophagy inhibition was further confirmed by silencing atg5, which is required for autophagy. Furthermore, PTV-2 replication was suppressed when autophagy was activated by rapamycin. Together, the results suggest that PTV-2 infection activates incomplete autophagy and that autophagy then inhibits further PTV-2 replication.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29177545</PMID>
<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>163</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Archives of virology</Title>
<ISOAbbreviation>Arch Virol</ISOAbbreviation>
</Journal>
<ArticleTitle>Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.</ArticleTitle>
<Pagination><MedlinePgn>623-632</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-017-3652-2</ELocationID>
<Abstract><AbstractText>Autophagy is a homeostatic process that has been shown to be vital in the innate immune defense against pathogens. However, little is known about the regulatory role of autophagy in porcine teschovirus 2 (PTV-2) replication. In this study, we found that PTV-2 infection induces a strong increase in GFP-LC3 punctae and endogenous LC3 lipidation. However, PTV-2 infection did not enhance autophagic protein degradation. When cellular autophagy was pharmacologically inhibited by wortmannin or 3-methyladenine, PTV-2 replication increased. The increase in virus yield via autophagy inhibition was further confirmed by silencing atg5, which is required for autophagy. Furthermore, PTV-2 replication was suppressed when autophagy was activated by rapamycin. Together, the results suggest that PTV-2 infection activates incomplete autophagy and that autophagy then inhibits further PTV-2 replication.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gu</LastName>
<ForeName>Yuanxing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Qingdao Agricultural University, Qingdao, 266109, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Yingshan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>College of Animal Science and Technology, China-Australia Joint-Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, Zhejiang A&F University, Lin'an, 311300, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Xinfeng</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Animal Products Quality Testing Center of Zhejiang Province, Hangzhou, 310020, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xin</LastName>
<ForeName>Yongping</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shan</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Cong</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Tong</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fang</LastName>
<ForeName>Weihuan</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xiaoliang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China. xlli@zju.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>2015C02044</GrantID>
<Agency>Department of S&T of Zhejiang Province</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>Y201635576</GrantID>
<Agency>Department of Education of Zhejiang Province</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2017ZDNT004</GrantID>
<Agency>Dabei Agricultural Discipline Development and Talent Training Fund</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>11</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Austria</Country>
<MedlineTA>Arch Virol</MedlineTA>
<NlmUniqueID>7506870</NlmUniqueID>
<ISSNLinking>0304-8608</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000730">Androstadienes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071187">Autophagy-Related Protein 5</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008869">Microtubule-Associated Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>147336-22-9</RegistryNumber>
<NameOfSubstance UI="D049452">Green Fluorescent Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>5142-23-4</RegistryNumber>
<NameOfSubstance UI="C025946">3-methyladenine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>JAC85A2161</RegistryNumber>
<NameOfSubstance UI="D000225">Adenine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>XVA4O219QW</RegistryNumber>
<NameOfSubstance UI="D000077191">Wortmannin</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000225" MajorTopicYN="N">Adenine</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000730" MajorTopicYN="N">Androstadienes</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071187" MajorTopicYN="N">Autophagy-Related Protein 5</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017930" MajorTopicYN="N">Genes, Reporter</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049452" MajorTopicYN="N">Green Fluorescent Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="Y">Host-Pathogen Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008869" MajorTopicYN="N">Microtubule-Associated Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052700" MajorTopicYN="N">Teschovirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000077191" MajorTopicYN="N">Wortmannin</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>10</Month>
<Day>11</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>11</Month>
<Day>28</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>2</Month>
<Day>21</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
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<ArticleIdList><ArticleId IdType="pubmed">29177545</ArticleId>
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<ArticleId IdType="pii">10.1007/s00705-017-3652-2</ArticleId>
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<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Zhejiang</li>
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<settlement><li>Hangzhou</li>
</settlement>
<orgName><li>Université de Zhejiang</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Gu, Yuanxing" sort="Gu, Yuanxing" uniqKey="Gu Y" first="Yuanxing" last="Gu">Yuanxing Gu</name>
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<name sortKey="Chen, Cong" sort="Chen, Cong" uniqKey="Chen C" first="Cong" last="Chen">Cong Chen</name>
<name sortKey="Fang, Weihuan" sort="Fang, Weihuan" uniqKey="Fang W" first="Weihuan" last="Fang">Weihuan Fang</name>
<name sortKey="Gu, Yuanxing" sort="Gu, Yuanxing" uniqKey="Gu Y" first="Yuanxing" last="Gu">Yuanxing Gu</name>
<name sortKey="Li, Xiaoliang" sort="Li, Xiaoliang" uniqKey="Li X" first="Xiaoliang" last="Li">Xiaoliang Li</name>
<name sortKey="Shan, Ying" sort="Shan, Ying" uniqKey="Shan Y" first="Ying" last="Shan">Ying Shan</name>
<name sortKey="Shi, Xinfeng" sort="Shi, Xinfeng" uniqKey="Shi X" first="Xinfeng" last="Shi">Xinfeng Shi</name>
<name sortKey="Xin, Yongping" sort="Xin, Yongping" uniqKey="Xin Y" first="Yongping" last="Xin">Yongping Xin</name>
<name sortKey="Zhou, Yingshan" sort="Zhou, Yingshan" uniqKey="Zhou Y" first="Yingshan" last="Zhou">Yingshan Zhou</name>
<name sortKey="Zhou, Yingshan" sort="Zhou, Yingshan" uniqKey="Zhou Y" first="Yingshan" last="Zhou">Yingshan Zhou</name>
</country>
</tree>
</affiliations>
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Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.

Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.

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